Sigma Aldrich 2-Chloro-1-(6-Methoxy-1 2 3 4-Tetrahydroquinolin-1-Yl)Ethan-1-One

Catalog No.	Quantity
91-213-1100MG	250 mg

Catalog No. 91-213-1100MG Supplier Sigma Aldrich Supplier No. 912131100MG

Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

2-Chloro-1-(6-methoxy-1,2,3,4-tetrahydroquinolin-1-yl)ethan-1-one is a cysteine-reactive small-molecule fragment for chemoproteomic and ligandability studies for both traditionally druggable proteins as well as undruggable, or difficult-to-target, proteins. This fragment electrophile, or scout fragment, can be used alone in fragment-based covalent ligand discovery or incorporated into bifunctional tools such as electrophilic PROTAC™ molecules for targeted protein degradation as demonstrated by the Cravatt Lab Lab for E3 ligase discovery.Technology Spotlight: Proteomic Ligandability AssessmentThe Proteome-Wide Potential for Reversible Covalency at CysteineElectrophilic PROTACs that degrade nuclear proteins by engaging DCAF16Proteome-wide covalent ligand discovery in native biological systems PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

• CAS: 194659-03-5
• Melting Point: >300°C
• Molecular Formula: C80H80N4O16Rh2
• Linear Formula: C80H80N4O16Rh2
• Quantity: 250 mg
• Synonym: Tetrakis[(S)-(+)-(1-adamantyl)-(N-phthalimido)acetato]dirhodium(II)
• Molecular Weight (g/mol): 1559.32 g/mol