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Cayman Chemical 2-Cl-IB-MECA 25mg

Supplier: Cayman Chemical 2733625 MG

A potent 5-HT2C receptor agonist (Ki 1 6 nM) selective for human 5-HT2C and rat 5-HT2C over human 5-HT2A 5-HT2B and rat 5-HT2A receptors in a FLIPR assay (EC50s 0 11 0 06 153 65 3 and 119 nM respectively) as well as human dopamine D2 histamine H1 and a1- and a2-adrenergic receptors (Kis 872 828 217 and 956 nM respectively) inhibits the conditioned avoidance response hyperactivity induced by PCP and D-amphetamine and spontaneous locomotor activity in rats (ED50s 4 8 2 4 2 9 and 2 mg/kg respectively) reduces reinstatement of drug-seeking behavior in cocaine-primed rats (0 01-1 g/0 2 l/side in central amygdala) reduces reinstatement of food-seeking behavior in a rat model of dietary relapse
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