Cayman Chemical 2-Cl-IB-MECA 25mg

Supplier:  Cayman Chemical 2733625 MG

An adenosine A3 receptor agonist; binds selectively to adenosine A3 receptors (Ki = 0.33 nM) over A1 and A2A receptors (Kis = 820 and 470 nM, respectively) and inhibits adenylate cyclase activity (IC50 = 66.8 nM); inhibits proliferation of B16/F10 melanoma cells and increases proliferation of murine bone marrow cells in vitro at 10 and 100 nM; induces accumulation of cells in the G0/G1 phase of the cell cycle and induces apoptosis at 100 nM; prevents the development of lung metastatic foci in a B16/F10 mouse model of lung metastasis and reverses decreases in the number of white blood cells and neutrophils induced by cyclophosphamide at 6 UG/kg

Catalog No. 50-293-9260