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Cayman Chemical 2-CMethylgunosIn 50mg
SDP

Supplier:  Cayman Chemical 3654850 MG

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A covalent BTK inhibitor (IC50 0 1 nM) 5000-fold selective for BTK over a panel of 240 kinases but does inhibit TEC BMX and TMX (IC50s 0 9 1 5 and 5 0 nM respectively) inhibits BCR stimulation-induced calcium flux in Ramos B cells (IC50 7 2 nM) as well as BCR stimulation-induced proliferation of and CD86 surface expression in peripheral B cells (IC50s 0 04 and 0 3 nM respectively) inhibits FcY receptor stimulation-induced TNF-a production in human PBMCs (IC50 0 3 nM) completely protective against bone destruction in a mouse model of collagen-induced arthritis at 0 5 mg/kg reduces proteinuria and glomerular IgG immune complex deposition and increases survival in an NZB/W lupus-prone mouse model

Catalog No. 50-291-3768


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