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Cayman Chemical 2-Deoxy-5-fluorocytIdIn 1g
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Supplier:  Cayman Chemical 374771 G

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An antimetabolite, a DNA methylation and dCK inhibitor, and a prodrug form of 5-FU; incorporation of 2'-deoxy-5-fluorocytidine into a synthetic DNA polymer inhibits methylation of DNA in a cell-free assay; 2'-deoxy-5-fluorocytidine-containing oligonucleotides form a covalent complex with Dnmt3a; inhibits dCK (IC50 = 120 nM); reduces the cytopathic effects of the influenza H5N1 strain Vietnam/1203/2004 in MDCK cells (IC50 = 0.19 µM); inhibits tumor growth in an ascitic mammary adenocarcinoma 755 murine model in combination with tetrahydrouridine; induces embryonic lethality and skeletal malformations when administered to pregnant mice

Catalog No. 50-291-5854


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