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Medchemexpress LLC 2-Deoxy-D-glucose | 154-17-6 | 99.9% | 164.16 | 25 G
Supplier: Medchemexpress LLC 25GHY13966
2-Deoxy-D-glucose is a glucose analog that acts as a competitive inhibitor of glucose metabolism, inhibiting glycolysis via its actions on hexokinase.
- Significantly reduces the level of ATP in MCF-7 cells in a dose- and time-dependent manner.
- Decreases phosphorylated Akt levels and increases phosphorylated AMPK and Sirt-1 levels in MCF-7 cells.
- Increases the levels of pentose phosphate pathway (PPP) metabolites and augments the generation of NADPH by glucose-6-phosphate dehydrogenase.
- Increases the reduced form of glutathione by 2-DG in NB4 cells.
- Causes a 7% decrease in final weight and delays the appearance of palpable mammary carcinomas in vivo.
- Decreased in a dose-dependent manner in rat muscle in vivo.
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