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Apexbio Technology LLC 2-Deoxy-D-glucose 154-17-6 1g
Supplier: Apexbio Technology LLC B10271000
2-Deoxy-D-glucose (2-DG) is a glucose analog that acts as a competitive inhibitor of glycolysis interfering with cellular glucose metabolism and ATP synthesis It suppresses glycolytic flux altering cellular energy levels and inducing metabolic stress In vitro studies demonstrate its cytotoxicity against the KIT-positive gastrointestinal stromal tumor (GIST) cell lines GIST882 and GIST430 with IC50 values of 0 5 M and 2 5 M respectively Additionally treatment with 2-DG impairs viral protein translation during early virus replication stages and can potentiate chemotherapeutic agents cytotoxicity in human cancer models supporting its applicability in metabolic pathway studies and cancer therapy research
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