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AdipoGen 2-Deoxy-D-glucose
Supplier: AdipoGen AGCR13681G005
Chemical. CAS 154-17-6. Formula C6H12O5. MW 164.2. . Non-metabolizable glucose analog. An indirect inhibitor of hexokinase HK, inhibiting the rate limiting step of glycolysis and consequently decreases glycolysis. Inhibits phosphorylation of glucose by hexokinase, which consequently results in the depletion in cellular ATP, the inhibition of protein glycosylation and the disruption of ER quality control by inducing the unfolded protein response. Useful agent for immunometabolism research. Anticancer agent. Shown to cause cell cycle inhibition and cell death in in vitro models of hypoxia, induce autophagy, increase reactive oxygen species production, activate AMPK, and block tumor cell growth in animal models. Potential antiviral agent.
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