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Cayman Chemical 2-Fluoro-2-deoxyurIdIn 10mg
Supplier: Cayman Chemical 4030210 MG
A derivative of ATP and an antagonist of the purinergic P2Y1 P2X3 and P2X2/3 receptors (IC50s 6 0.9 and 7 nM respectively in HEK293 cells expressing the human receptors) selective for these receptors over the purinergic P2X2 P2X4 and P2X7 receptors (IC50s 2 15.2 and 30 UM respectively in HEK293 cells expressing the human receptors) decreases acetic acid-induced calcium flux in 1321N1 cells expressing the P2X3 and P2X2/3 receptors (IC50s 100 and 62 nM respectively) reduces the number of abdominal constrictions induced by acetic acid in a mouse model of visceral pain (ED50 6.35 Umol/kg) ex/em maxima 403 and 547 nm respectively relative fluorescence increases four-fold when bound to IDE with an em maxima at 538 nm
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