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Apexbio Technology LLC 2-hexyl-4-Pentynoic Acid 96017-59-3 1g
Supplier: Apexbio Technology LLC B59691000
2-hexyl-4-Pentynoic Acid (CAS 96017-59-3) is a valproic acid derivative that functions as a histone deacetylase (HDAC) inhibitor exhibiting an IC50 of 13 M HDACs regulate gene expression by removing acetyl groups from histones promoting chromatin condensation and transcriptional repression In cerebellar granule cells 2-hexyl-4-Pentynoic Acid increases acetylated histone H3 levels in a dose-dependent manner and enhances HSP70-1a/1b mRNA expression At 50 100 M it significantly elevates Ac-H3 levels beyond those achieved with valproic acid and provides complete protection against glutamate-induced cell death indicating its utility in neuroprotection and epigenetic research
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