2-Iodoacetamide, 98%, stab. with ca 5-8% water

Description

CAS: 144-48-9 | C2H4INO | 184.964 g/mol

Alkylating agent used in peptide mapping because it covalently binds with the thiols in cysteine to prevent disulfide bond formation2-Iodoacetamide is used as an electrophile for covalent modification of nucleophilic residues on proteins such as cysteine, methionine and histidine. It is used to bind with thiol group of cysteine, thereby it protects the formation disulfide bonds. It is involved as an inhibitor of deubiquitinase enzymes (DUBs). Further, it acts as an alkylating sulfhydryl reagent.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Alkylating agent used in peptide mapping because it covalently binds with the thiols in cysteine to prevent disulfide bond formation2-Iodoacetamide is used as an electrophile for covalent modification of nucleophilic residues on proteins such as cysteine, methionine and histidine. It is used to bind with thiol group of cysteine, thereby it protects the formation disulfide bonds. It is involved as an inhibitor of deubiquitinase enzymes (DUBs). Further, it acts as an alkylating sulfhydryl reagent.

Solubility
Soluble in water, dimethyl formamide and ethanol. Slightly soluble in methanol.

Notes
Store in a cool place. Light and moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents.

Specifications

Chemical Identifiers

• CAS: 144-48-9
• Molecular Formula: C2H4INO
• Molecular Weight (g/mol): 184.964
• MDL Number: MFCD00008028
• InChI Key: PGLTVOMIXTUURA-UHFFFAOYSA-N
• Synonym: iodoacetamide, monoiodoacetamide, surauto, acetamide, 2-iodo, 2-iodo-acetamide, usaf d-1, alpha-iodoacetamide, ccris 7710, unii-zrh8m27s79, n-3-methoxy-4-butoxybenzyl thiobarbituric acid
• PubChem CID: 3727
• IUPAC Name: 2-iodoacetamide
• SMILES: C(C(=O)N)I

• Melting Point: 92°C to 95°C (dried)
• Odor: Characteristic
• Assay Percent Range: 98%, stabilized with ca 5% water
• Quantity: 100 g
• UN Number: UN2811
• Beilstein: 1739080
• Sensitivity: Light sensitive
• Solubility Information: Soluble in water,dimethyl formamide and ethanol. Slightly soluble in methanol.
• Formula Weight: 184.96
• Percent Purity: 98%
• Chemical Name or Material: 2-Iodoacetamide, stabilized with ≈5 to 8% water

Safety and Handling

Hazard Category	H301-H314-H317-H334-H335
Hazard Statement	GHS H Statement H301-H315-H319-H317-H335 Toxic if swallowed. Causes skin irritation. Causes serious eye irritation. May cause an allergic skin reaction. May cause respiratory irritation.
Precautionary Statement	P260-P264b-P270-P271-P272-P280-P285-P303+P361+P353-P304+P340-P305+P351+P338-P310-P330-P331-P333+P313-P363-P501c
DOTInformation	Transport Hazard Class: 6.1; Packing Group: III; Proper Shipping Name: TOXIC SOLIDS, ORGANIC, N.O.S.
EINECSNumber	205-630-1
RTECSNumber	AC4200000
TSCA	Yes
Recommended Storage	Keep cold

SDS

RUO – Research Use Only