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Medchemexpress LLC 2-Methyl-1,2,5,6-tetrahydro-3H-pyrrolo[3,2,1-ij]quinazolin-3-imine hydrochloride | C11H14ClN3 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY151500B5MG

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JBSNF-000028 hydrochloride is an orally active, small molecule inhibitor of tricyclic nicotinamide N-methyltransferase (NNMT) with IC50 values of 33 nM for human NNMT. It effectively reduces endogenous MNA levels in U2OS osteosarcoma cells with an EC50 of 2.5 μM. This compound has demonstrated significant anti-obesity and anti-diabetic activities in diet-induced obesity models.

  • Inhibits NNMT activity with an EC50 of 2.5 μM in U2OS cells
  • Shows no cytotoxicity against HepG2 cells at 10-100 μM
  • Improves glucose and lipid handling in mice with diet-induced obesity
  • Improves glucose tolerance in NNMT knockout mice with diet-induced obesity
  • Used for studying metabolic diseases such as obesity, type 2 diabetes, and non-alcoholic fatty liver disease

Catalog No. 50-003-73033


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