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Cayman Chemical 2-methyl-4-phenyl ThIazole 1g

Supplier: Cayman Chemical 133861 G

A CysLT1 receptor antagonist (Ki 2 1 nM in a radioligand binding assay using isolated human lung membranes) inhibits contractions induced by LTD4 or LTE4 in histamine-primed isolated guinea pig trachea (pA2 9 4 and 9 1 respectively) but not contractions induced by LTC4 in histamine-primed isolated guinea pig trachea at 190 nM inhibits LTD4-induced calcium mobilization in COS-7 cells expressing the human CysLT1 receptor at 100 nM improves tissue damping and elasticity markers of lung function and decreases IL-4 and IL-5 levels in BALF in a mouse model of ovalbumin-induced asthma at 5 mg/kg
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