2-Methylanisole, 99%

Description

CAS: 578-58-5 | C8H10O | 122.167 g/mol

The catalytic system of disubstituted aromatics was optimized for the 2-methylanisole reduction by a proper choice of the amine/Rh ratio which should be high enough to stabilize very small colloidal rhodium particles and low enough to avoid deactivation. The total synthesis of (±)-heliannuol D and its epimer has been completed in 9 steps and 12% overall yield from 2-methylanisole. The thermal activation of 2-methylanisole (60°C) by the Ir (III) complex TpMe2Ir (C6H5) 2 (N2)(1; TpMe2= hydrotris (3, 5-dimethylpyrazolyl) borate) yielded a mixture of hydride complexes. The total synthesis of the phenolic sesquiterpene mutisianthol has been accomplished in 12 steps from the readily available 2-methylanisole. The catalytic system was optimized for the 2-methylanisole reduction by a proper choice of the amine/Rh ratio which should be high enough to stabilize very small colloidal rhodium particles and low enough to avoid deactivation.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
The catalytic system of disubstituted aromatics was optimized for the 2-methylanisole reduction by a proper choice of the amine/Rh ratio which should be high enough to stabilize very small colloidal rhodium particles and low enough to avoid deactivation. The total synthesis of (±)-heliannuol D and its epimer has been completed in 9 steps and 12% overall yield from 2-methylanisole. The thermal activation of 2-methylanisole (60°C) by the Ir (III) complex TpMe2Ir (C6H5) 2 (N2)(1; TpMe2= hydrotris (3, 5-dimethylpyrazolyl) borate) yielded a mixture of hydride complexes. The total synthesis of the phenolic sesquiterpene mutisianthol has been accomplished in 12 steps from the readily available 2-methylanisole. The catalytic system was optimized for the 2-methylanisole reduction by a proper choice of the amine/Rh ratio which should be high enough to stabilize very small colloidal rhodium particles and low enough to avoid deactivation.

Solubility
Insoluble in water.

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents.

Specifications

Chemical Identifiers

• CAS: 578-58-5
• Molecular Formula: C8H10O
• Molecular Weight (g/mol): 122.167
• MDL Number: MFCD00008373
• InChI Key: DTFKRVXLBCAIOZ-UHFFFAOYSA-N
• Synonym: 2-methylanisole, o-methylanisole, 2-methoxytoluene, o-cresol methyl ether, o-cresyl methyl ether, anisole, o-methyl, benzene, 1-methoxy-2-methyl, methyl o-tolyl ether, o-methoxytoluene, 2-methylmethoxybenzene
• PubChem CID: 33637
• IUPAC Name: 1-methoxy-2-methylbenzene
• SMILES: CC1=CC=CC=C1OC

• Density: 0.985
• Boiling Point: 170°C to 172°C
• Flash Point: 51°C (123°F)
• Refractive Index: 1.517
• Quantity: 250 g
• UN Number: UN3271
• Beilstein: 1857415
• Solubility Information: Insoluble in water.
• Formula Weight: 122.17
• Percent Purity: 99%
• Chemical Name or Material: 2-Methylanisole

Safety and Handling

Hazard Category	H226
Hazard Statement	GHS H Statement H226 Flammable liquid and vapour.
Precautionary Statement	P210-P233-P240-P241-P242-P243-P280-P303+P361+P353-P370+P378q-P501c
DOTInformation	Transport Hazard Class: 3; Packing Group: III; Proper Shipping Name: ETHERS, N.O.S.
EINECSNumber	209-426-3
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only