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Sigma Aldrich 2-(Piperidin-4-Yl)Benzoic Acid Hydrochloride

Catalog No. 916854100MG Shop All MilliporeSigma Sigma Organic Chemistry Products
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91-685-4100MG 250 mg
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Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

2-(Piperidin-4-yl)benzoic acid hydrochloride is a 4-aryl piperidine useful as a semi-flexible linker in PROTAC development for targeted protein degradation. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties.Portal: Building PROTAC™ Degraders for Targeted Protein DegradationCrosslinkers for BioconjugationTechnology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

CAS 110990-09-5
Molecular Formula C19H16NOP
Linear Formula C19H16NOP
Quantity 250 mg
Synonym 2-(Diphenylphosphino)-benzamide; DPBM; Phosphine for Staundinger reduction
Molecular Weight (g/mol) 305.31 g/mol
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