Medchemexpress LLC 2-propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)-, (2E)- | 18550-98-6 | 98.95% | 210.23 | 100 MG

Supplier:  Medchemexpress LLC HY19824100MG

3PO, also known as 2-Propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)-, (2E)-, is a potent inhibitor of PFKFB3. This compound effectively attenuates the proliferation of various cancer cell lines by suppressing glucose uptake and reducing the intracellular concentrations of key metabolic intermediates like Fru-2,6-BP, lactate, ATP, NAD+, and NADH. It is commonly utilized in cancer research for its role in influencing cell cycle and inhibiting glycolytic flux.

• Inhibits PFKFB3, a key enzyme in glycolysis.
• Attenuates proliferation of multiple cancer cell lines.
• Suppresses cellular glucose uptake.
• Decreases intracellular concentrations of Fru-2,6-BP, lactate, ATP, NAD+, and NADH.
• Induces G2-M phase cell cycle arrest in certain cell types.
• Used extensively in cancer research studies.
• Demonstrates activity in both in vitro and in vivo models.

Catalog No. 50-004-00776