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Medchemexpress LLC 2-Propen-1-one, 3-(3-pyridinyl)-1-(4-pyridinyl)-, (2E)- | 18550-98-6 | 99.0% | 210.23 | 25 MG
Supplier: Medchemexpress LLC 25MGHY19824
3PO is an inhibitor of PFKFB3, used in cancer research. It attenuates the proliferation of several cancer cell lines with IC50s of 1.4-24 μmol/L. 3PO suppresses glucose uptake and decreases the intracellular concentration of Fru-2,6-BP, lactate, ATP, NAD+ and NADH.
- Inhibits Jurkat cells proliferation by influencing the cell cycle.
- Suppresses glycolytic flux to lactate in Jurkat cells.
- Inhibits cellular proliferation of transformed tumor cell lines.
- Inhibits Jurkat T cells proliferation by G2-M phase cell cycle arrest.
- Decreases lactate secretion, NADH, NAD+, and ATP in Jurkat cells.
- Inhibited solid tumor and hematologic cell lines (Jurkat, K562, HL-60, MDA-MB231, HeLa, Melanoma, and Lewis Lung) with IC50s of 1.4-24 μM/L.
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