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Medchemexpress LLC 2-Propenethioamide, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (2E)- | 148741-30-4 | 99.3% | 316.46 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY20878

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Tyrphostin AG 879 (AG 879) is a tyrosine kinase inhibitor that inhibits TrKA phosphorylation with an IC50 of 10 μM, but not TrKB and TrKC. It is also a selective ErbB2 tyrosine kinase inhibitor with an IC50 of 1 μM, showing at least 500-fold higher selectivity for ErbB2 over EGFR. This compound exhibits anticancer activity.

  • Significantly decreases cell proliferation in various cell lines
  • Induces a dose-dependent increase in apoptosis
  • Reduces tumor sizes in animal models

Catalog No. 50-004-02443


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