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Medchemexpress LLC 2-Pyrazinecarboxamide, 6-ethyl-3-[[4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]amino]-5-[[(3R)-1-(1-oxo-2-propen-1-yl)-3-pyrrolidinyl]oxy]-, methanesulfonate (1:1) | 1448237-05-5 | 98.1% | 658.81 | 100 MG
SDP

Supplier:  Medchemexpress LLC HY19803100MG

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Naquotinib mesylate (ASP8273 mesylate) is an orally available, mutant-selective and irreversible EGFR inhibitor. It inhibits the growth of various EGFR-dependent cells and selectively inhibits phosphorylation of EGFR and its downstream signal pathway, ERK and Akt.

  • Mutant-selective and irreversible EGFR inhibitor
  • Inhibits growth of PC-9(del ex19), HCC827(del ex19), NCI-H1975(del ex19/T790M) and PC-9ER(del ex19/T790M) cells
  • Selectively inhibits phosphorylation of EGFR and its downstream signal pathways, ERK and Akt
  • Induces tumor regression in NCI-H1975 (L858R/T790M), HCC827 (del ex19), and PC-9 (del ex19) xenograft models

Catalog No. 50-004-01920


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