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Medchemexpress LLC 2-Pyrazinemethanol, 5-[(2R)-4-[4,5-dimethyl-6-(phenylmethyl)-3-pyridazinyl]-2-methyl-1-piperazinyl]-a,a-dimethyl- | 1204975-42-7 | 98.92% | 432.56 | 50 MG
SDP

Supplier:  Medchemexpress LLC HY1863650MG

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LEQ506 is a second-generation inhibitor of smoothened (Smo) with IC50s of 2 and 4 nM in human and mouse, respectively. It inhibits Hedgehog (Hh) signaling in a human cell line (HEPM) and shows a tendency to preferentially inhibit Gli1 rather than Ptch1 mRNA. It is efficacious in decreasing Gli1 mRNA by approximately 70% to 80%.

  • Second-generation inhibitor of smoothened (Smo).
  • IC50s of 2 nM (human smo) and 4 nM (mouse smo).
  • Inhibits Hedgehog (Hh) signaling in a human cell line.
  • Efficacious in decreasing Gli1 mRNA by approximately 70% to 80%.
  • Shows a tendency to preferentially inhibit Gli1 over Ptch1 mRNA.

Catalog No. 50-003-87962


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