Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
Learn More
Medchemexpress LLC 2-Pyridinamine, 5,6-bis(4-methoxy-3-methylphenyl)- | 2306039-66-5 | 99.8% | C21H22N2O2 | 100 MG
Supplier: Medchemexpress LLC HY141482100MG
WSB1 Degrader 1 is a potent and orally active WSB1 (WD repeat and SOCS box-containing 1) degrader, exhibiting anticancer metastatic effects.
- Induces WSB1 degradation in H1299-WSB1 cells.
- Exhibits potent antimigration efficacy in KHOS and H460 cell lines.
- Significantly inhibits cancer cell migration under normoxia and hypoxia in KHOS cells.
- Elevates RhoGDI2 protein levels in KHOS cells under hypoxia.
- Significantly inhibits wound-healing of H1299-WSB1 cells.
- Blocks wound-healing capability of wild-type A2780 cells.
- Effectively inhibits pulmonary metastasis of cancer cells in mice bearing highly metastatic 4T1 breast cancer cells.
- Shows quick absorption and acceptable blood exposure in rats after oral or intraperitoneal dosing.
Product Title
By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.
Spot an opportunity for improvement?