Medchemexpress LLC 2-Pyridinamine, 5,6-bis(4-methoxy-3-methylphenyl)- | 2306039-66-5 | 99.8% | C21H22N2O2 | 50 MG

Supplier:  Medchemexpress LLC HY14148250MG

WSB1 Degrader 1 is a potent and orally active degrader of WSB1 (WD repeat and SOCS box-containing 1). It exhibits anticancer metastatic effects. In vitro studies show it induces WSB1 degradation in H1299-WSB1 cells in a time-dependent and dose-dependent manner. It also demonstrates potent antimigration efficacy in KHOS and H460 cell lines. In vivo, daily oral treatment effectively inhibited pulmonary metastasis in Balb/c (nu/nu) mice bearing highly metastatic 4T1 breast cancer cells.

• Induces WSB1 degradation in H1299-WSB1 cells
• Exhibits potent antimigration efficacy in KHOS and H460 cell lines
• Significantly inhibits cancer cell migration under normoxia and hypoxia in KHOS cells
• Elevates RhoGDI2 protein levels in KHOS cells under hypoxia
• Blocks the wound-healing capability of wild-type A2780 cells
• Effectively inhibits pulmonary metastasis of cancer cells in animal models

Catalog No. 50-003-55544