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Medchemexpress LLC 2-Pyridinecarboxamide, N-[3-chloro-4-[[(2-chlorophenyl)amino]sulfonyl]phenyl]- | 1246086-78-1 | C18H13Cl2N3O3S | 1 ML
SDP

Catalog No. 5000376494
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VU 0364439 is a mGlu4 positive allosteric modulator (PAM) with an EC50 of 19.8 nM. It demonstrates positive allosteric modulation of the human mGlu4 receptor, expressed in CHO cells, by potentiating glutamate-induced calcium mobilization. While showing better stability in human liver microsomes (HLM) with 63% remaining than rat liver microsomes (RLM) with 2% remaining, its pharmacokinetic properties are less than ideal, limiting its direct use as an in vivo tool.

  • Acts as a mGlu4 positive allosteric modulator
  • Has an EC50 of 19.8 nM
  • Potentiates glutamate-induced calcium mobilization in human mGlu4 receptor
  • Exhibits better stability in HLM (63% remaining) than RLM (2% remaining)

Catalog No. 50-003-76494 Supplier Medchemexpress LLC Supplier No. HY1547610MM/1ML
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VU 0364439 is a mGlu4 positive allosteric modulator (PAM) with an EC50 of 19.8 nM. It demonstrates positive allosteric modulation of the human mGlu4 receptor, expressed in CHO cells, by potentiating glutamate-induced calcium mobilization. While showing better stability in human liver microsomes (HLM) with 63% remaining than rat liver microsomes (RLM) with 2% remaining, its pharmacokinetic properties are less than ideal, limiting its direct use as an in vivo tool.

  • Acts as a mGlu4 positive allosteric modulator
  • Has an EC50 of 19.8 nM
  • Potentiates glutamate-induced calcium mobilization in human mGlu4 receptor
  • Exhibits better stability in HLM (63% remaining) than RLM (2% remaining)

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