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Apexbio Technology LLC 2-Thio-UTP(Synonyms: 2-Thiouridine-5'-triphosphate, 2-Thio-uridine triphosphate, 2-S-UTP, 2-Thio-UTP sodium salt), 100ul (100 mM).
SDP

Supplier:  Apexbio Technology LLC B79840.1

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2-Thio-UTP is a base-modified ribonucleoside triphosphate commonly used in RNA-based biomedical research Incorporation of 2-Thio-UTP into RNA transcripts reduces innate immune activation compared to unmodified RNA Mechanistically RNAs transcribed with 2-Thio-UTP lack the ability to activate RNA-dependent protein kinase (PKR) markedly diminish 2 -5 -oligoadenylate synthetase (OAS) pathway induction decrease recognition by retinoic acid-inducible gene I (RIG-I) and suppress Toll-like receptor (TLR) mediated signaling Thus 2-Thio-UTP serves as a research tool in studies designing low-immunogenic RNAs for therapeutic applications

Catalog No. 50-000-60246


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