Cayman Chemical 2-ThIothInonhydrochlorIde 10mg

Supplier:  Cayman Chemical 900210110 MG

A VEGFR2 inhibitor (IC50 42 nM) selective for VEGFR2 over FMS PDGFRa FLT3 and KIT (IC50s 624 1109 nM 4810 and 511 nM respectively) and VEGFR1 and VEGFR3 (IC50s 4451 and 1112 nM respectively) but does inhibit RET (IC50 183 nM) decreases VEGF-induced phosphorylation of VEGFR2 in serum-starved HUVECs at 10 100 or 500 nM inhibits VEGF-induced migration in HUVECs at 1 UM reduces Vegf-induced corneal neovascularization in mice at 100 mg/kg decreases tumor size in an HCT116 mouse xenograft model at 10-200 mg/kg per day reduces polyp number in an Apc /Min-FCCC mouse model of spontaneous colorectal adenoma at 100 mg/kg per day

Catalog No. 50-289-2856