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Abcam 20(S)-Hydro x ycholesterol, Smoothened activator, 5MG
Supplier: Abcam AB1461465MG
MW 402.65 g/mol. Allosteric activator of the Hedgehog (Hh) signaling pathway Smoothened (Smo) oncoprotein. Binds at a site distinct from the canonical cyclopamine binding site. Activates Hh signaling (EC₅₀ = ~ 3 μM for induction of Hh reporter gene transcription in NIH 3T3 cells). Also exhibits osteogenic activity and activates the liver X receptor (LXR).
The product is subject to the following: Abcam Restricted Use Statement
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