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Cayman Chemical 2amIno PyrIdyl5thIoamIde 100mg
Supplier: Cayman Chemical 13389100 MG
A dual inhibitor of class I PI3Ks and mTOR (IC50s 4 75 7 and 5 nM for p110a - B - and -Y respectively) and mTOR (IC50 20 nM) selective for these enzymes over a panel of kinases (IC50s 10 UM for all) inhibits proliferation of and induces apoptosis in MCF-7 MDA-MB-468 SK-BR-3 and MDA-MB-361 breast cancer cells at 0 1 or 1 UM reduces tumor growth in a U87MG mouse xenograft model at 25 35 or 45 mg/kg
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