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Cayman Chemical 2AmInopurInhydrochLRIde 100mg

Supplier: Cayman Chemical 18609100 MG

A highly potent and selective inhibitor of DOT1L histone methyltransferase activity (Ki 80 pM) inhibits the H3K79 methylation in various human leukemia cell lines (IC50s 3-5 nM) decreasing MLL-fusion target gene expression and inhibiting proliferation intravenous infusion of EPZ-5676 at a dose of 35 mg/kg can regress tumors in a rat xenograft model of MLL-rearranged leukemia
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