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Medchemexpress LLC 2H-1-Benzopyran-7-ol, 3,4-dihydro-3-(4-hydroxyphenyl)-4-(4-methoxyphenyl)-, (3R,4S)-rel- | 1213777-80-0 | 723112 | 99.6% | C22H20O4 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY14570

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Triphen diol is a phenol diol derivative known for its excellent anticancer activity against pancreatic cancer and cholangiocarcinoma. It induces pancreatic cell apoptosis through both caspase-mediated and caspase-independent mechanisms, and is intended for research use only.

  • Inhibits proliferation of pancreatic cells (IC50 values: 8 μM for HPAC and PANC-1; 0.8 μM for MIAPaCa-2).
  • Induces caspase-dependent apoptosis in MIAPaCa-2 and PANC-1 cells (60% early-stage, 30% late-stage).
  • Reduces Bcl-2 levels in MIAPaCa-2 and HPAC cell lines.
  • Significantly inhibits tumor proliferation in male Balb/c nude mice with MIAPaCa2 cells.
  • Shows enhanced efficacy when combined with gemcitabine in vivo.

Catalog No. 50-003-56623


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