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Medchemexpress LLC 2H-Benzimidazol-2-one, 1,3-dihydro-1-[2-hydroxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)- | 153587-01-0 | 98.1% | 362.23 | 25 MG
SDP

Supplier:  Medchemexpress LLC 25MGHY12496

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NS-1619 is an opener of large conductance Ca2+-activated K+ (BK) channel. It acts as a highly effective relaxant with an EC50 of approximately 10-30 μM in various smooth muscles of blood vessels and other tissues. It also inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells.

  • Opens large conductance Ca2+-activated K+ (BK) channel.
  • Functions as a highly effective relaxant in smooth muscles of blood vessels and other tissues (EC50 of about 10-30 μM).
  • Inhibits proliferation and induces apoptosis in A2780 ovarian cancer cells.
  • Increases levels of p53, p21Cip1, and Bax proteins in A2780 cells.
  • Causes a significant decrease in DNA content of A2780 cells, leading to tumor cell death.
  • Can induce delayed protection against ischemia-reperfusion injury in mouse hearts.

Catalog No. 50-004-38743


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