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Medchemexpress LLC 2H-Indazole-7-carboxamide, 2-[4-[1-[17-[4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-2-oxo-1-piperazinyl]-16-oxo-3,6,9,12-tetraoxa-15-azaheptadec-1-yl]-1H-1,2,3-triazol-4-yl]phenyl]- rel- | 99.0% | 1145.09 | 1 MG
SDP

Supplier:  Medchemexpress LLC HY114324A1MG

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rel-PROTAC PARP1 degrader is the relative configuration of ROTAC PARP1 degrader (HY-114324). ROTAC PARP1 degrader is a PARP1 degrader based on MDM2 E3 ligand. It induces significant PARP1 cleavage and programmed cell death. PROTAC PARP1 degrader at 10 μM at 24 h inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM.

  • Relative configuration of ROTAC PARP1 degrader
  • Based on MDM2 E3 ligand
  • Induces significant PARP1 cleavage
  • Induces programmed cell death
  • Appearance: solid
  • Color: white to off-white
  • Inhibits MDA-MB-231 cell line with an IC50 of 6.12 μM at 10 μM at 24 h

Catalog No. 50-004-36876


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