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Medchemexpress LLC (2S,4R)-1-[(2S)-2-[(1-cyanocyclopropanecarbonyl)amino]-3,3-dimethylbutanoyl]-4-hydroxy | 2097381-85-4 | MFCD30742947 | >98.0% | 523.65 g/mol | C27H33N5O4S | 2 MG
SDP

Supplier:  Medchemexpress LLC HY1009472MG

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VH-298 is a potent, cell-permeable small molecule that inhibits the VHL:HIF-α protein-protein interaction, stabilizing HIF-α and inducing a hypoxic response in cells. It is commonly used as a chemical probe and as an E3 ligase ligand in the design of PROTACs for cell-based studies.

  • High binding affinity (Kd ≈ 80-90 nM).
  • Cell-permeable and reported non-toxic in cellular assays.
  • Induces HIF-α accumulation in treated cells.
  • Useful as an E3 ligase ligand for PROTAC construction.
  • Supplied as a small-molecule solid suitable for synthesis and biological assays.

Catalog No. 50-002-11825


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