Medchemexpress LLC (2S,4R)-1-((S)-2-(1-cyanocyclopropane-1-carboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylt | 2097381-85-4 | MFCD30742947 | 99.5% | 523.65 g/mol | C27H33N5O4S | 50 MG

Supplier:  Medchemexpress LLC HY10094750MG

VH-298 is a cell-permeable inhibitor of the VHL:HIF-α interaction that induces HIF-α accumulation and serves as an E3 ligase ligand for PROTAC synthesis. It is potent (Kd 80-90 nM), shows minimal off-target activity in broad panels, and is suitable as a chemical probe for studying hypoxic response and targeted protein degradation.

• Highly potent VHL:HIF-α interaction inhibitor (Kd 80-90 nM).
• Induces HIF-α accumulation in human cell lines.
• Functions as an E3 ligase ligand for PROTAC synthesis.
• Cell-permeable with low cellular toxicity.
• Minimal off-target activity across kinase, GPCR, and ion channel panels at 50 μM.
• High purity and defined storage and solubility profiles for experimental use.

Catalog No. 50-002-13012