Sigma Aldrich (3-(1,1-Difluoro-3-(Triisopropylsilyl)Prop-2-Yn-1-Yl)-3H-Diazirin-3-Yl)Methanol

Catalog No.	Quantity
90-730-850MG	1 g

Catalog No. 90-730-850MG Supplier Sigma Aldrich Supplier No. 90730850MG

Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

(3-(1,1-Difluoro-3-(triisopropylsilyl)prop-2-yn-1-yl)-3H-diazirin-3-yl)methanol is a minimally interfering photo-affinity label (MI-PAL). Photoaffinity labeling is of growing interest in chemical biology and drug discovery research to characterize the non-covalent interactome and is used in protein profiling; the study of protein-protein interactions and complexes; and target engagement, identification, or validation studies. This MI-PAL contains a diazirine for UV light-induced (∼365 nm) covalent modification of a biological target with potential for downstream applications via the click chemistry-enabling alkyne tag. Its small size exhibits minimal perturbation of the interactions between proteins and the ligand or probe. The Woo lab demonstrated the electronic tuning of this MI-PAL with the placement of stability-imparting fluorine groups adjacent to the diazirine and alkyne. The alkyl fluorine ion losses are also a useful marker in collision-induced dissociation (CID) mass spectrometry experiments. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.Synthesis of an electronically-tuned minimally interfering alkynyl photo-affinity label to measure small moleculeeprotein interactions

Specifications

• CAS: 83152-22-1
• Melting Point: >300°C
• Molecular Formula: C17H14B2F8N4Pd
• Linear Formula: C17H14B2F8N4Pd
• Quantity: 1 g
• Molecular Weight (g/mol): 554.35 g/mol