Medchemexpress LLC 3-(3,4-dimethoxyphenyl)-N5-(pentamethylpiperidin-4-yl)-6-phenylpyrazolo[1,5-a]pyrimidine-5,7-diamine | 2561413-77-0 | 99.6% | C30H38N6O2 | 10MG

Supplier:  Medchemexpress LLC HY13355110MG

WF-47-JS03 is a potent, selective RET kinase inhibitor for research use. It inhibits RET-driven cellular models at low-nanomolar concentrations, shows greater than 500-fold selectivity over KDR, and has demonstrated brain penetration in preclinical studies. The compound is reported with high chemical purity and is supplied in small solid quantities and as a DMSO solution for laboratory experiments.

• Potent RET inhibition in cellular assays (KIF5B-RET IC50 1.7 nM).
• Active against CCDC6-RET with low-nanomolar potency (IC50 5.3 nM).
• High selectivity against KDR (>500-fold).
• Demonstrated brain penetration in preclinical models.
• High chemical purity suitable for biochemical and cellular experiments.
• Available in small-scale solid formats and as a DMSO solution.

Catalog No. 50-002-58508