3,3',5-Triiodo-L-thyronine, 95%

Description

CAS: 6893-02-3 | C15H12I3NO4 | 650.98 g/mol

Using video intensification fluorescence microscopy and tetramethylrhodamine (Rho)-labeled 3, 3', 5-triiodo-L-thyronine (T3),the uptake of T3 by cultured mouse fibroblasts was studied. The binding of 3, 3', 5-triiodo-L-thyronine (T3) to GH3 rat pituitary tumor cells was studied at 15 degrees C and was shown to be saturable, reversible, and stereospecific. A fluorescent derivative of the thyroid hormone 3,3'-triiodo-L-thyronine binds to cultured mouse fibroblasts; such binding is saturable. 3,3?,5-Triiodo-L-thyronine Up-regulation of Na,K-ATPase Activity and Cell Surface Expression in Alveolar Epithelial Cells Is Src Kinase- and Phosphoinositide 3-Kinase-dependent.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
Using video intensification fluorescence microscopy and tetramethylrhodamine (Rho)-labeled 3, 3′, 5-triiodo-L-thyronine (T3),the uptake of T3 by cultured mouse fibroblasts was studied. The binding of 3, 3′, 5-triiodo-L-thyronine (T3) to GH3 rat pituitary tumor cells was studied at 15 degrees C and was shown to be saturable, reversible, and stereospecific. A fluorescent derivative of the thyroid hormone 3,3′-triiodo-L-thyronine binds to cultured mouse fibroblasts; such binding is saturable. 3,3′,5-Triiodo-L-thyronine Up-regulation of Na,K-ATPase Activity and Cell Surface Expression in Alveolar Epithelial Cells Is Src Kinase- and Phosphoinositide 3-Kinase-dependent.

Solubility
Insoluble in water, ethanol and propylene glycol. Soluble in dilute alkalies.

Notes
Light Sensitive. Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Store away from strong oxidizing agents, Strong bases, light.

Specifications

Chemical Identifiers

• CAS: 6893-02-3
• Molecular Formula: C15H12I3NO4
• Molecular Weight (g/mol): 650.98
• MDL Number: MFCD00002593
• InChI Key: AUYYCJSJGJYCDS-UHFFFAOYNA-N
• Synonym: liothyronine, triiodothyronine, 3,3',5-triiodo-l-thyronine, liothyronin, tresitope, 3,5,3'-triiodothyronine, l-liothyronine, triothyrone, liothyroninum, liotironina
• PubChem CID: 5920
• ChEBI: CHEBI:18258
• IUPAC Name: (2S)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-diiodophenyl]propanoic acid
• SMILES: C1=CC(=C(C=C1OC2=C(C=C(C=C2I)CC(C(=O)O)N)I)I)O

• Melting Point: 234°C to 238°C
• Quantity: 250 mg
• Sensitivity: Light sensitive
• Solubility Information: Insoluble in water,ethanol and propylene glycol. Soluble in dilute alkalies.
• Optical Rotation: +25° (c=1 in 1M HCl/Ethanol 1:2)
• Formula Weight: 650.97
• Percent Purity: 95%
• Chemical Name or Material: 3,3',5-Triiodo-L-thyronine

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	229-999-3
RTECSNumber	AY6750000
TSCA	No
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only