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Medchemexpress LLC 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one | 18550-98-6 | MFCD00224002 | >98.0% | 210.23 g/mol | C13H10N2O | 10 MG
SDP

Supplier:  Medchemexpress LLC HY1982410MG

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3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) is a small-molecule inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3) used as a research probe to study glycolysis and cancer cell metabolism. It reduces glycolytic flux and glucose uptake, lowers intracellular fructose-2,6-bisphosphate, lactate, ATP, and NAD+/NADH, and shows cellular activity in the low micromolar range.

  • Inhibits PFKFB3 activity with low micromolar potency.
  • Attenuates proliferation of multiple cancer cell lines.
  • Reduces glucose uptake and glycolytic metabolites.
  • Cell-permeable small molecule suitable for cell-based assays.
  • Commonly supplied at high purity for research applications.
  • Useful for studies of cancer metabolism and autophagy.

Catalog No. 50-002-96936


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