Sigma Aldrich 3-(4-Bromophenyl)-3-(Trifluoromethyl)-3H-Diazirine

Catalog No.	Quantity
90-629-850MG	50 mg

Catalog No. 90-629-850MG Supplier Sigma Aldrich Supplier No. 90629850MG

Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

3-(4-Bromophenyl)-3-(trifluoromethyl)-3H-diazirine is a Suzuki-Miyaura (S-M)-compatible building block tailored for the design of photoaffinity probes (PAPs). Photoaffinity labeling (PAL) is of growing interest in chemical biology and drug discovery research for use in protein profiling; covalent inhibitors; protein-protein interactions and complexes; and target engagement, identification, or validation studies. Diazirines are desirable photoactivable groups for chemical probes; however, their installation is not always straightforward. In response, diazirine-tolerant S-M coupling conditions were developed by Ichiishi, et al, using 3-(4-bromophenyl)-3-(trifluoromethyl)-3H-diazirine and shown to be efficient and scalable with minimal perturbation of the diazirine.Reducing Limitation in Probe Design: The Development of a Diazirine-Compatible Suzuki-Miyaura Cross Coupling Reaction

Specifications

• CAS: 2227157-06-2
• Molecular Formula: C28H39N7O6S
• Linear Formula: C28H39N7O6S
• Quantity: 50 mg
• Synonym: (2S,4R)-1-((S)-2-(2-(2-(2-Azidoethoxy)ethoxy)acetamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; Crosslinker-E3 ligase ligand conjugate; Protein degrader building block for PROTAC(R) research; Template for synthesis of targeted protein degrader; VH032 conjugate
• Molecular Weight (g/mol): 601.72 g/mol