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Sigma Aldrich 3-(7-(Tert-Butoxycarbonyl)-5 6 7 8-Tetrahydroimidazo[1 2-A]Pyrazin-3-Yl)Propanoic Acid

Catalog No. 92050950MG Shop All MilliporeSigma Sigma Organic Chemistry Products
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Description

MilliporeSigma Sigma Organics products encompass a wide range of quality reagents, solvents, catalysts, and building blocks for organic synthesis. From benchtop discovery to process development and scale-up, Sigma Organics solutions are built to meet the needs of synthetic chemists.

3-(7-(tert-Butoxycarbonyl)-5,6,7,8-tetrahydroimidazo[1,2-a]pyrazin-3-yl)propanoic acid is useful as a rigid linker in PROTAC development for targeted protein degradation as well as chemical conjugates. Incorporation of rigidity into the linker region of bifunctional protein degraders may impact the 3D orientation of the degrader and thus ternary complex formation as well as optimization of drug-like properties. Developed in partnership with ComInnex.Similar linkers in this series:920568920657ENAH38A2CCD6AC5372910424Portal: Building PROTAC™ Degraders for Targeted Protein DegradationCrosslinkers for BioconjugationTechnology Spotlight: Degrader Building Blocks for Targeted Protein DegradationPROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Specifications

CAS 21149-17-7
Linear Formula C6H5CH2O2CNHC(=CH2)CO2CH3
Quantity 50 mg
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