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Apexbio Technology LLC 3-aminobenzamide 3544-24-9 500mg
Supplier: Apexbio Technology LLC A4161500
3-Aminobenzamide (CAS 3544-24-9) is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) exhibiting an IC50 of approximately 50 nM in CHO cell assays At concentrations above 1 M it suppresses over 95% of PARP activity without notable cytotoxicity In cellular models 3-aminobenzamide mitigates oxidative stress-induced endothelial dysfunction by enhancing acetylcholine-induced nitric oxide-mediated vasodilation following hydrogen peroxide exposure In vivo it has been shown to attenuate diabetic nephropathy in Leprdb/db mice by reducing albuminuria glomerular mesangial expansion and podocyte loss 3-Aminobenzamide serves as a valuable tool for PARP-related research in oxidative injury and metabolic disease models
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