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Apexbio Technology LLC 3-Bromopyruvic acid(Synonyms: 3-Bromopyruvate, 3-BrPA, β-Bromopyruvic acid, β-Bromopyruvate, Bromopyruvic acid, Bromopyruvate), 1g, CAS: 1113-59-3.
Supplier: Apexbio Technology LLC B79221000
3-Bromopyruvic acid (CAS 1113-59-3) abbreviated as 3-BP is a small molecule inhibitor that targets hexokinase II (HK2) an enzyme notably upregulated in cancerous cells By inhibiting HK2 activity (Ki 2 4 mM) 3-BP interferes with glycolytic energy metabolism leading to reduced tumor cell proliferation in hepatocellular carcinoma BEL-7402 cells In mouse xenograft models of hepatocellular carcinoma administration of 3-BP (50 mg/kg/day six days weekly for three weeks) results in decreased tumor growth and increased tumor necrosis This compound serves as a tool in oncology research particularly for studying glycolysis-dependent tumor metabolism
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