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Medchemexpress LLC 3-chloro-4,7-difluoro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thi | 612542-14-0 | MFCD12032128 | 99.9% | 526.04 | C28H26ClF2N3OS | 25MG
SDP

Supplier:  Medchemexpress LLC HY12489925MG

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Hh-Ag1.5 (SAg1.5) is a potent small-molecule agonist of the Hedgehog signaling pathway that activates the Smoothened (Smo) receptor. It is supplied as a white to off-white solid with high reported purity and is used as a research tool to activate Hh signaling in cellular and in vivo studies. The compound is highly soluble in DMSO and has documented storage recommendations for powder and solutions.

  • Potent Hedgehog pathway agonist with EC50 ≈ 1 nM.
  • Activates Smoothened to induce downstream GLI transcription activity.
  • High purity suitable for research (99.9%).
  • Soluble in DMSO at 50 mg/mL; in vivo formulations achievable at ≥2.5 mg/mL.
  • Stable as powder when stored cold; aliquot solutions to avoid freeze-thaw.
  • Demonstrated biological activity in liver stem cell expansion at 5 μM in vitro.

Catalog No. 50-002-37882


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