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Cayman Chemical 3-formyl RIfamycIn 5g
SDP

Supplier:  Cayman Chemical 202605 G

Encompass_Preferred

A PAD4 inhibitor (IC50 200 nM in the absence of calcium) selectively inhibits the production of citrulline by PAD4 over PAD1 PAD2 and PAD3 in kinetic assays prevents ionomycin-induced histone H3 citrullination and NET formation in isolated mouse peripheral blood neutrophils at 10 UM reduces HCoV-OC43 replication in infected MRC-5 cells (IC50 0 6 UM) reduces complement C3 deposition in the synovium and cartilage at 10 and 30 mg/kg and reduces disease severity at 30 mg/kg in a mouse model of collagen-induced arthritis reduces plasma NET levels and brain infarct volume as well as improves neurological outcomes in a mouse model of tMCAO-induced ischemic stroke at 30 mg/kg

Catalog No. 50-298-3378


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