3-Hydroxy-4-methoxybenzaldehyde, 98%

Description

CAS: 621-59-0 | C8H8O3 | 152.149 g/mol

3-Hydroxy-4-methoxybenzaldehyde acts as a precursor for the stereoselective synthesis of the anticancer drug (Z)-combretastatin A-4 and glycitein. It also used as an important raw material for the preparation of morphine. Further, it is involved in the preparation of Schiff- bases by reacting with furan-2-carboxylic acid hydrazide and thiophene-2-carboxylic acid hydrazide. In addition to this, it is used to prepare (Z)-2-(3-hydroxy-4-methoxybenzylidene)-1-azabicyclo[2.2.2]octan-3-one by reacting with with1-azabicyclo[2.2.2]octan-3-one.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
3-Hydroxy-4-methoxybenzaldehyde acts as a precursor for the stereoselective synthesis of the anticancer drug (Z)-combretastatin A-4 and glycitein. It also used as an important raw material for the preparation of morphine. Further, it is involved in the preparation of Schiff- bases by reacting with furan-2-carboxylic acid hydrazide and thiophene-2-carboxylic acid hydrazide. In addition to this, it is used to prepare (Z)-2-(3-hydroxy-4-methoxybenzylidene)-1-azabicyclo[2.2.2]octan-3-one by reacting with with1-azabicyclo[2.2.2]octan-3-one.

Solubility
Soluble in acetone and methanol.

Notes
Air sensitive. Store in a cool place. Incompatible with strong oxidizing agents and strong bases.

Specifications

Chemical Identifiers

• CAS: 621-59-0
• Molecular Formula: C8H8O3
• Molecular Weight (g/mol): 152.149
• MDL Number: MFCD00003369
• InChI Key: JVTZFYYHCGSXJV-UHFFFAOYSA-N
• Synonym: isovanillin, isovanilline, 3-hydroxy-p-anisaldehyde, 5-formylguaiacol, benzaldehyde, 3-hydroxy-4-methoxy, iso-vanillin, 3-hydroxyanisaldehyde, isovanilin, isovanicaline, 3-hydroxy-4-methoxy-benzaldehyde
• PubChem CID: 12127
• IUPAC Name: 3-hydroxy-4-methoxybenzaldehyde
• SMILES: COC1=C(C=C(C=C1)C=O)O

• Melting Point: 112°C to 116°C
• Density: 1.2
• Boiling Point: 179°C (15 mmHg)
• Flash Point: >110°C (230°F)
• Quantity: 5 g
• Beilstein: 1073021
• Sensitivity: Air and light sensitive
• Solubility Information: Soluble in acetone and methanol.
• Formula Weight: 152.15
• Percent Purity: 98%
• Chemical Name or Material: 3-Hydroxy-4-methoxybenzaldehyde

Safety and Handling

Hazard Category	H315-H319-H335
Hazard Statement	GHS H Statement H315-H319-H335 Causes skin irritation. Causes serious eye irritation. May cause respiratory irritation.
Precautionary Statement	P261-P264b-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P362-P501c
EINECSNumber	210-694-9
RTECSNumber	CU6540000
TSCA	Yes
Recommended Storage	Ambient temperatures

SDS

RUO – Research Use Only