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Cayman Chemical 3-HydroxygenkwnIn 10mg
Supplier: Cayman Chemical 3615010 MG
A RIPK1 inhibitor (IC50 13 nM) selective for RIPK1 over RIPK3 at 10 UM as well as over a panel of additional kinases at 2 UM inhibits Z-VAD-FMK-induced necrosis in HT-29 cells (EC50 28 nM) reduces TNF-a-induced lethality and protects against TNF-a-induced organ damage in a mouse model of SIRS at 6 mg/kg reduces spinal cord demyelination and BBB breakdown in a mouse model of EAE reduces hepatic inflammatory cell infiltration and fibrosis as well as body weight gain and total fat mass in a mouse model of high-fat diet-induced NASH at 300 mg/kg
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