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Cayman Chemical 3-MethylglutaconIc AcId 250mg

Supplier: Cayman Chemical 34055250 MG

A peptide ETB receptor antagonist (IC50 1.2 nM) selective for ETB over ETA receptors (IC50 280 nM) as well as angiotensin calcitonin or neuropeptide receptors at 10 UM inhibits ET-1-induced calcium mobilization in human Girrardi heart cells (IC50 0.54 nM) and BQ-3020-induced vasoconstriction in isolated rat pulmonary arteries (pA2 8.4) inhibits ET-1 induced depressor responses and induces pressor responses in rats at 1 mg/kg protects against laparotomy and surgical gut handling-induced inhibition of intestinal motility in rats attenuates delayed hypotension vascular hyporeactivity to norepinephrine and hepatocellular injury and dysfunction in a rat model of LPS-induced endotoxemia
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