Apexbio Technology LLC 3'-O-Methyl-GTP 50ul (100 mM)

Supplier:  Apexbio Technology LLC B80380.05

3 -O-Methyl-GTP is a methylated nucleotide analogue designed to serve as a chain terminator during RNA synthesis Structurally this molecule contains a methyl modification at the nucleotide s 3 -hydroxyl position enabling it to interact specifically with RNA polymerase active sites and subsequently pause or halt RNA polymerization Mechanistically its incorporation into nascent RNA transcripts prevents further phosphodiester bond formation thus interrupting RNA elongation Given these properties 3 -O-Methyl-GTP represents a useful tool for examining transcriptional regulation processes RNA polymerase function and investigating the molecular dynamics underlying RNA replication and transcription mechanisms Applications of this compound include biochemical assays molecular biology experiments and studies exploring the molecular pathways involved in RNA-related diseases

Catalog No. 50-000-63663