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Medchemexpress LLC 3-Quinolineethanol, 6-bromo-α-(2,6-dimethoxy-4-pyridinyl)-α-[2-(dimethylamino)ethyl]-β-(2-fluoro-3-methoxyphenyl)-2-methoxy- | 2252316-16-6 | 99.7% | 614.50 | 25 MG
SDP

Catalog No. 5000439893
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TBAJ-587 is a potent anti-tuberculosis agent, an analogue of Bedaquiline, demonstrating more potent anti-tubercular activity. It inhibits *M.tb* strain H37Rv growth with MIC90s of 0.006 and <0.02 μg/mL in MABA and LORA assays, respectively. A key feature of TBAJ-587 is its greatly attenuated inhibition of the cardiac potassium channel protein hERG compared to Bedaquiline, with an IC50 of 13 μM for hERG channel inhibition, thus reducing cardiac liability.

  • Potent anti-tuberculosis agent.
  • Inhibits *M.tb* strain H37Rv growth.
  • Minimally inhibits the hERG channel.
  • Reduces cardiac liability compared to Bedaquiline.

Catalog No. 50-004-39893 Supplier Medchemexpress LLC Supplier No. 25MGHY111747
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TBAJ-587 is a potent anti-tuberculosis agent, an analogue of Bedaquiline, demonstrating more potent anti-tubercular activity. It inhibits *M.tb* strain H37Rv growth with MIC90s of 0.006 and <0.02 μg/mL in MABA and LORA assays, respectively. A key feature of TBAJ-587 is its greatly attenuated inhibition of the cardiac potassium channel protein hERG compared to Bedaquiline, with an IC50 of 13 μM for hERG channel inhibition, thus reducing cardiac liability.

  • Potent anti-tuberculosis agent.
  • Inhibits *M.tb* strain H37Rv growth.
  • Minimally inhibits the hERG channel.
  • Reduces cardiac liability compared to Bedaquiline.

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