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Medchemexpress LLC 3-thiopheneacetamide, N-[(5-chloro-2-propoxyphenyl)methyl]-N-[2-[4-[(2-propyn-1-ylamino)sulfonyl | 2454246-18-3 | MFCD32263442 | 99.7% | 545.11 g·mol-1 | C27H29ClN2O4S2 | 5 MG
SDP

Supplier:  Medchemexpress LLC HY1302525MG

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YQ128 is a potent, selective, second-generation small-molecule inhibitor of the NLRP3 inflammasome intended for research use. It inhibits NLRP3-mediated IL-1β production (reported IC50 ~0.30 μM), exhibits anti-inflammatory activity, and is reported to cross the blood-brain barrier. The molecule contains an alkyne functional group enabling copper-catalyzed azide-alkyne cycloaddition for conjugation applications.

  • Potent NLRP3 inflammasome inhibition (IC50 ~0.30 μM).
  • Selectively suppresses IL-1β without inhibiting TNF-α.
  • Shows anti-inflammatory activity in cellular models.
  • Reported to cross the blood-brain barrier.
  • Contains an alkyne group for click-chemistry conjugation.
  • Provided as a research reagent with high reported purity.

Catalog No. 50-002-62869


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