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Apexbio Technology LLC 360A iodide 737763-37-0 50mg
Supplier: Apexbio Technology LLC A312050
360A iodide (CAS 737763-37-0) is a 2 6-pyridine-dicarboxamide derivative that acts as a selective ligand for G-quadruplex DNA structures By stabilizing telomeric G-quadruplexes 360A inhibits telomerase activity and induces alterations in cell cycle progression notably causing S-phase accumulation in ATM-proficient EBV-lymphocytes Its mechanism of action involves promoting sister telomere fusions via DNA-PKcs-dependent non-homologous end joining (NHEJ) as well as triggering NHEJ and homologous recombination (HR) pathways at telomeres which disrupt mitotic progression 360A has been shown to preferentially bind telomeric G-quadruplex DNA over duplex DNA and to delay growth in HT1080 tumor cells This compound is valuable for investigating telomere biology DNA damage response and G-quadruplex-mediated genomic stability
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