Cayman Chemical 3a-AmInocholestn 10mg

Supplier:  Cayman Chemical 2788510 MG

An inhibitor of SHP-1 (IC50 = ~2.5 µM); selective for SHP-1 over SHP-2 and PTEN (IC50s = >20 µM); induces hyperactivation of SYK in patient-derived Ph+ ALL cells; reduces leukemia burden and increases survival in a tyrosine kinase inhibitor-resistant patient-derived Ph+ ALL mouse xenograft model at 50 mg/kg; reduces cell viability of OPM2 cells in a concentration-dependent manner and of RPMI8226 cells at ≥12.5 µM; halts the cell cycle at the G0/G1 or G2/M stages in the highly proliferative OPM2 or less proliferative RPMI8226 cell lines, respectively; induces apoptosis via activation of caspase-3, caspase-9, and PARP in OPM2 cells but not in RPMI8226 cells

Catalog No. 50-293-8133